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Filtered Search Results
eMolecules 69026-14-8 | Ambeed | 3-Benzyloxybenzoic acid | 1g | 570997388 | A292611 | MFCD00527901 | 228.247 | C14H12O3
Ambeed | 3-Benzyloxybenzoic acid | 1g | 570997388 | A292611 | 69026-14-8 | MFCD00527901 | 228.247 | C14H12O3
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Selleck Chemical LLC Amuvatinib (MP-470) S1244-2mg
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Amuvatinib (MP-470 HPK 56) is a potent and multi-targeted inhibitor of c-Kit PDGFR and Flt3 with IC50 of 10 nM 40 nM and 81 nM respectively Amuvatinib suppresses c-MET and c-RET Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity Phase 2
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Apexbio Technology LLC Mecamylamine hydrochloride 826-39-1 10mg
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Mecamylamine hydrochloride (CAS 826-39-1) is an orally active non-selective non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) capable of crossing the blood-brain barrier It inhibits the amplitude of induced end plate currents at a holding potential of 70 mV with an IC50 of 7 8 M and a Hill coefficient of 1 2 indicating moderate cooperativity In behavioral studies intraperitoneal administration of mecamylamine (0 5 1 mg/kg) in C57BL/6J mice produces antidepressant-like effects in both the tail suspension and forced swim tests effects which are dependent on the 2 and 7 nAChR subunits This compound is widely utilized in neuropsychiatric and neuropharmacological research
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Selleck Chemical LLC Doravirine
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Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12 9 7 and 9 7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants respectively in a biochemical assay It is highly specific with minimum off-target activities
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Selleck Chemical LLC Erdafitinib
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Erdafitinib is a potent and selective orally bioavailable pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity Erdafitinib also binds to RET (c-RET) CSF-1R PDGFR- /PDGFR- FLT4 Kit (c-Kit) and VEGFR-2 and induces cellular apoptosis
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Medchemexpress LLC Lyp-1 tfa | 99.52% | 1106.16 | 5 MG
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LyP-1 TFA is a cyclic 9 amino acids tumor homing peptide that selectively binds to p32 receptors which are overexpressed in various tumor-associated cells. For research use only, not for sale to patients.
- Shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group (in vivo studies).
- Higher apoptotic rate in macrophages released from hypoxic plaques observed after LyP-1 treatment compared to control peptide (in vivo studies).
- Can be labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
- Exhibits lymphatics-specific binding.
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eMolecules 357-70-0 | Medchem Express | Galanthamine | 50mg | 446271480 | HY-76299 | MFCD00867189 | 287.359 | C17H21NO3
Ambeed | 5-Methyl-2-(4455-tetramethyl-132-dioxaborolan-2-yl)aniline | 100mg | 704973383 | A767206 | 863578-36-3 | MFCD06795679 | 233.120 | C13H20BNO2
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Sigma Aldrich Fine Chemicals Biosciences LY344864 hydrochloride >=98% (HPLC) | 1217756-94-9 | 5MG
LY344864 hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 387.88 | 1217756-94-9 | 5MG
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Medchemexpress LLC HY-100131 100mg Medchemexpress, GSK'481 GSK481 CAS:1622849-58-4 Purity:98%
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Medchemexpress,HY-100131 100mg GSK'481 GSK481 CAS:1622849-58-4 Formula:C21H19N3O4 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Selleck Chemical LLC BAW2881
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BAW2881 (NVP-BAW2881) is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1 0-4 3 nanomolar (nM) concentrations and inhibits PDGFR c-Kit and RET (c-RET) at 45-72 nM concentrations
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eMolecules 1013750-77-0 | Medchem Express | ML-030 | 5mg | 446257942 | HY-103050 | 412.46 | C20H20N4O4S
Ambeed | 2-(4455-Tetramethyl-132-dioxaborolan-2-yl)-9H-fluoren-9-one | 250mg | 696731920 | A334841 | 1021306-45-5 | MFCD16294551 | 306.170 | C19H19BO3
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Medchemexpress LLC Ly2365109 hydrochloride | 1779796-27-8 | 98.7% | 421.91 | C22H28ClNO5 | 25 MG
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LY2365109 hydrochloride is a potent, selective glycine transporter 1 (GlyT1) inhibitor that increases glycine levels in cerebrospinal fluid and raises seizure thresholds in preclinical models. It is provided as a solid research reagent with characterized purity and stability profiles.
- Potent and selective GlyT1 inhibitor, IC50 15.8 nM for glycine uptake.
- Elevates CSF glycine levels in preclinical studies.
- Shown to increase seizure thresholds in animal models.
- High purity suitable for research use (98.69%).
- White to off-white solid, molecular weight 421.91, formula C22H28ClNO5.
- Soluble in DMSO (≥31 mg/mL) and insoluble in water (<0.1 mg/mL).
- Recommended storage sealed at 4°C; in solvent store at -80°C for long term.
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eMolecules 5273-86-9 | Medchem Express | Beta-asarone | 5mg | 533802727 | HY-N1501 | MFCD00009281 | 208.257 | C12H16O3
Medchem Express | Beta-asarone | 5mg | 533802727 | HY-N1501 | 5273-86-9 | MFCD00009281 | 208.257 | C12H16O3
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Medchemexpress LLC GNE-371 | 1926986-36-8 | 98.06% | 431.49 | 100 MG
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GNE-371 is a potent and selective chemical probe designed to target the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like. It demonstrates an IC50 of 10 nM for TAF1(2).
- Potent and selective chemical probe for TAF1(2) bromodomains.
- Binds TAF1(2) with an IC50 of 10 nM.
- Maintains excellent selectivity over other bromodomain-family members.
- Active in cellular-TAF1(2) target-engagement assay (IC50=38 nM).
- Exhibits anti-proliferative synergy with the BET inhibitor JQ1.
- Supports use in mechanistic and target-validation studies.
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Selleck Chemical LLC Telaglenastat
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Telaglenastat (CB-839) is a potent selective and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC CB-839(Telaglenastat) inudces autophagy and has antitumor activity Phase 1
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